Tryptophan metabolism activation by indoleamine 2,3-dioxygenase in adipose tissue of obese women: an attempt to maintain immune homeostasis and vascular tone
Identifieur interne : 005792 ( Main/Exploration ); précédent : 005791; suivant : 005793Tryptophan metabolism activation by indoleamine 2,3-dioxygenase in adipose tissue of obese women: an attempt to maintain immune homeostasis and vascular tone
Auteurs : Isabelle Wolowczuk [France] ; Benjamin Hennart [France] ; Audrey Leloire [France] ; Alban Bessede [Australie] ; Marion Soichot [France] ; Solenne Taront [France] ; Robert Caiazzo [France] ; Violeta Raverdy [France] ; Marie Pigeyre [France] ; Abos Consortium [France] ; Gilles J. Guillemin [Australie] ; Delphine Allorge [France] ; François Pattou [France] ; Philippe Froguel [France, Royaume-Uni] ; Odile Poulain-Godefroy [France]Source :
- American journal of physiology. Regulatory, integrative and comparative physiology [ 0363-6119 ] ; 2012.
Descripteurs français
- Pascal (Inist)
- Wicri :
English descriptors
- KwdEn :
Abstract
Human obesity is characterized by chronic low-grade inflammation in white adipose tissue and is often associated with hypertension. The potential induction of indoleamine 2,3-dioxygenase-1 (IDO1), the rate-limiting enzyme in tryptophan/ kynurenine degradation pathway, by proinflammatory cytokines, could be associated with these disorders but has remained unexplored in obesity. Using immunohistochemistry, we detected IDO1 expression in white adipose tissue of obese patients, and we focused on its contribution in the regulation of vascular tone and on its immunoregulatory effects. Concentrations of tryptophan and kynurenine were measured in sera of 36 obese and 15 lean women. The expression of IDO1 in corresponding omental and subcutaneous adipose tissues and liver was evaluated. Proinflammatory markers and T-cell subsets were analyzed in adipose tissue via the expression of CD14, IL-18, CD68, TNFα, CD3ε, FOXP3 [a regulatory T-cell (Treg) marker] and RORC (a Th 17 marker). In obese subjects, the ratio of kynurenine to tryptophan, which reflects IDO1 activation, is higher than in lean subjects. Furthermore, IDO1 expression in both adipose tissues and liver is increased and is inversely correlated with arterial blood pressure. Inflammation is associated with a T-cell infiltration in obese adipose tissue, with predominance of Thl7 in the omental compartment and of Treg in the subcutaneous depot. The Th17/Treg balance is decreased in subcutaneous fat and correlates with IDO1 activation. In contrast, in the omental compartment, despite IDO1 activation, the Th17/Treg balance control is impaired. Taken together, our results suggest that IDO1 activation represents a local compensatory mechanism to limit obesity-induced inflammation and hypertension.
Affiliations:
- Australie, France, Royaume-Uni
- Angleterre, Grand Londres, Hauts-de-France, Nord-Pas-de-Calais
- Lille, Londres
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000F19
- to stream PascalFrancis, to step Curation: 005002
- to stream PascalFrancis, to step Checkpoint: 000C26
- to stream Main, to step Merge: 005A61
- to stream Main, to step Curation: 005792
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Tryptophan metabolism activation by indoleamine 2,3-dioxygenase in adipose tissue of obese women: an attempt to maintain immune homeostasis and vascular tone</title><author><name sortKey="Wolowczuk, Isabelle" sort="Wolowczuk, Isabelle" uniqKey="Wolowczuk I" first="Isabelle" last="Wolowczuk">Isabelle Wolowczuk</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centre National de la Recherche Scientifique, UMR 8199, Pasteur Institute, Université Lille Nord de France</s1><s2>Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Hennart, Benjamin" sort="Hennart, Benjamin" uniqKey="Hennart B" first="Benjamin" last="Hennart">Benjamin Hennart</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>EA4483, Faculty of Medicine, Université Lille Nord de France</s1><s2>Lille</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Leloire, Audrey" sort="Leloire, Audrey" uniqKey="Leloire A" first="Audrey" last="Leloire">Audrey Leloire</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centre National de la Recherche Scientifique, UMR 8199, Pasteur Institute, Université Lille Nord de France</s1><s2>Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Bessede, Alban" sort="Bessede, Alban" uniqKey="Bessede A" first="Alban" last="Bessede">Alban Bessede</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Neuroinflammation Group, Department of Pharmacology, University of New South Wales</s1><s2>Sydney, New South Wales</s2><s3>AUS</s3><sZ>4 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Sydney, New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Soichot, Marion" sort="Soichot, Marion" uniqKey="Soichot M" first="Marion" last="Soichot">Marion Soichot</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>EA4483, Faculty of Medicine, Université Lille Nord de France</s1><s2>Lille</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Taront, Solenne" sort="Taront, Solenne" uniqKey="Taront S" first="Solenne" last="Taront">Solenne Taront</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centre National de la Recherche Scientifique, UMR 8199, Pasteur Institute, Université Lille Nord de France</s1><s2>Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Caiazzo, Robert" sort="Caiazzo, Robert" uniqKey="Caiazzo R" first="Robert" last="Caiazzo">Robert Caiazzo</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Institut National de la Santé et de la Recherche Médicale, UMR 859, Université Lille Nord de France</s1><s2>Lille</s2><s3>FRA</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Raverdy, Violeta" sort="Raverdy, Violeta" uniqKey="Raverdy V" first="Violeta" last="Raverdy">Violeta Raverdy</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Institut National de la Santé et de la Recherche Médicale, UMR 859, Université Lille Nord de France</s1><s2>Lille</s2><s3>FRA</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Pigeyre, Marie" sort="Pigeyre, Marie" uniqKey="Pigeyre M" first="Marie" last="Pigeyre">Marie Pigeyre</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Institut National de la Santé et de la Recherche Médicale, UMR 859, Université Lille Nord de France</s1><s2>Lille</s2><s3>FRA</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Consortium, Abos" sort="Consortium, Abos" uniqKey="Consortium A" first="Abos" last="Consortium">Abos Consortium</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Institut National de la Santé et de la Recherche Médicale, UMR 859, Université Lille Nord de France</s1><s2>Lille</s2><s3>FRA</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Guillemin, Gilles J" sort="Guillemin, Gilles J" uniqKey="Guillemin G" first="Gilles J." last="Guillemin">Gilles J. Guillemin</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Neuroinflammation Group, Department of Pharmacology, University of New South Wales</s1><s2>Sydney, New South Wales</s2><s3>AUS</s3><sZ>4 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Sydney, New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Allorge, Delphine" sort="Allorge, Delphine" uniqKey="Allorge D" first="Delphine" last="Allorge">Delphine Allorge</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>EA4483, Faculty of Medicine, Université Lille Nord de France</s1><s2>Lille</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Pattou, Francois" sort="Pattou, Francois" uniqKey="Pattou F" first="François" last="Pattou">François Pattou</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Institut National de la Santé et de la Recherche Médicale, UMR 859, Université Lille Nord de France</s1><s2>Lille</s2><s3>FRA</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centre National de la Recherche Scientifique, UMR 8199, Pasteur Institute, Université Lille Nord de France</s1><s2>Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Genomics of Common Disease, School of Public Health, Imperial College London</s1><s2>London</s2><s3>GBR</s3><sZ>14 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Poulain Godefroy, Odile" sort="Poulain Godefroy, Odile" uniqKey="Poulain Godefroy O" first="Odile" last="Poulain-Godefroy">Odile Poulain-Godefroy</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centre National de la Recherche Scientifique, UMR 8199, Pasteur Institute, Université Lille Nord de France</s1><s2>Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">12-0416204</idno><date when="2012">2012</date><idno type="stanalyst">PASCAL 12-0416204 INIST</idno><idno type="RBID">Pascal:12-0416204</idno><idno type="wicri:Area/PascalFrancis/Corpus">000F19</idno><idno type="wicri:Area/PascalFrancis/Curation">005002</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000C26</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000C26</idno><idno type="wicri:doubleKey">0363-6119:2012:Wolowczuk I:tryptophan:metabolism:activation</idno><idno type="wicri:Area/Main/Merge">005A61</idno><idno type="wicri:Area/Main/Curation">005792</idno><idno type="wicri:Area/Main/Exploration">005792</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Tryptophan metabolism activation by indoleamine 2,3-dioxygenase in adipose tissue of obese women: an attempt to maintain immune homeostasis and vascular tone</title><author><name sortKey="Wolowczuk, Isabelle" sort="Wolowczuk, Isabelle" uniqKey="Wolowczuk I" first="Isabelle" last="Wolowczuk">Isabelle Wolowczuk</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centre National de la Recherche Scientifique, UMR 8199, Pasteur Institute, Université Lille Nord de France</s1><s2>Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Hennart, Benjamin" sort="Hennart, Benjamin" uniqKey="Hennart B" first="Benjamin" last="Hennart">Benjamin Hennart</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>EA4483, Faculty of Medicine, Université Lille Nord de France</s1><s2>Lille</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Leloire, Audrey" sort="Leloire, Audrey" uniqKey="Leloire A" first="Audrey" last="Leloire">Audrey Leloire</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centre National de la Recherche Scientifique, UMR 8199, Pasteur Institute, Université Lille Nord de France</s1><s2>Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Bessede, Alban" sort="Bessede, Alban" uniqKey="Bessede A" first="Alban" last="Bessede">Alban Bessede</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Neuroinflammation Group, Department of Pharmacology, University of New South Wales</s1><s2>Sydney, New South Wales</s2><s3>AUS</s3><sZ>4 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Sydney, New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Soichot, Marion" sort="Soichot, Marion" uniqKey="Soichot M" first="Marion" last="Soichot">Marion Soichot</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>EA4483, Faculty of Medicine, Université Lille Nord de France</s1><s2>Lille</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Taront, Solenne" sort="Taront, Solenne" uniqKey="Taront S" first="Solenne" last="Taront">Solenne Taront</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centre National de la Recherche Scientifique, UMR 8199, Pasteur Institute, Université Lille Nord de France</s1><s2>Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Caiazzo, Robert" sort="Caiazzo, Robert" uniqKey="Caiazzo R" first="Robert" last="Caiazzo">Robert Caiazzo</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Institut National de la Santé et de la Recherche Médicale, UMR 859, Université Lille Nord de France</s1><s2>Lille</s2><s3>FRA</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Raverdy, Violeta" sort="Raverdy, Violeta" uniqKey="Raverdy V" first="Violeta" last="Raverdy">Violeta Raverdy</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Institut National de la Santé et de la Recherche Médicale, UMR 859, Université Lille Nord de France</s1><s2>Lille</s2><s3>FRA</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Pigeyre, Marie" sort="Pigeyre, Marie" uniqKey="Pigeyre M" first="Marie" last="Pigeyre">Marie Pigeyre</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Institut National de la Santé et de la Recherche Médicale, UMR 859, Université Lille Nord de France</s1><s2>Lille</s2><s3>FRA</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Consortium, Abos" sort="Consortium, Abos" uniqKey="Consortium A" first="Abos" last="Consortium">Abos Consortium</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Institut National de la Santé et de la Recherche Médicale, UMR 859, Université Lille Nord de France</s1><s2>Lille</s2><s3>FRA</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Guillemin, Gilles J" sort="Guillemin, Gilles J" uniqKey="Guillemin G" first="Gilles J." last="Guillemin">Gilles J. Guillemin</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Neuroinflammation Group, Department of Pharmacology, University of New South Wales</s1><s2>Sydney, New South Wales</s2><s3>AUS</s3><sZ>4 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Sydney, New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Allorge, Delphine" sort="Allorge, Delphine" uniqKey="Allorge D" first="Delphine" last="Allorge">Delphine Allorge</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>EA4483, Faculty of Medicine, Université Lille Nord de France</s1><s2>Lille</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Pattou, Francois" sort="Pattou, Francois" uniqKey="Pattou F" first="François" last="Pattou">François Pattou</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Institut National de la Santé et de la Recherche Médicale, UMR 859, Université Lille Nord de France</s1><s2>Lille</s2><s3>FRA</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centre National de la Recherche Scientifique, UMR 8199, Pasteur Institute, Université Lille Nord de France</s1><s2>Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Genomics of Common Disease, School of Public Health, Imperial College London</s1><s2>London</s2><s3>GBR</s3><sZ>14 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Poulain Godefroy, Odile" sort="Poulain Godefroy, Odile" uniqKey="Poulain Godefroy O" first="Odile" last="Poulain-Godefroy">Odile Poulain-Godefroy</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centre National de la Recherche Scientifique, UMR 8199, Pasteur Institute, Université Lille Nord de France</s1><s2>Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>6 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">American journal of physiology. Regulatory, integrative and comparative physiology</title><title level="j" type="abbreviated">Am. j. physiol., Regul. integr. comp. physiol.</title><idno type="ISSN">0363-6119</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">American journal of physiology. Regulatory, integrative and comparative physiology</title><title level="j" type="abbreviated">Am. j. physiol., Regul. integr. comp. physiol.</title><idno type="ISSN">0363-6119</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Activation</term><term>Adipose tissue</term><term>Chronic</term><term>Enzyme</term><term>Female</term><term>Homeostasis</term><term>Human</term><term>Hypertension</term><term>Induction</term><term>Inflammation</term><term>Metabolism</term><term>Nutritional status</term><term>Obesity</term><term>Tryptophan</term><term>White adipose tissue</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Tryptophane</term><term>Métabolisme</term><term>Activation</term><term>Tissu adipeux</term><term>Femelle</term><term>Homéostasie</term><term>Obésité</term><term>Chronique</term><term>Hypertension artérielle</term><term>Inflammation</term><term>Tissu adipeux blanc</term><term>Induction</term><term>Enzyme</term><term>Homme</term><term>Etat nutritionnel</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Enzyme</term><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Human obesity is characterized by chronic low-grade inflammation in white adipose tissue and is often associated with hypertension. The potential induction of indoleamine 2,3-dioxygenase-1 (IDO1), the rate-limiting enzyme in tryptophan/ kynurenine degradation pathway, by proinflammatory cytokines, could be associated with these disorders but has remained unexplored in obesity. Using immunohistochemistry, we detected IDO1 expression in white adipose tissue of obese patients, and we focused on its contribution in the regulation of vascular tone and on its immunoregulatory effects. Concentrations of tryptophan and kynurenine were measured in sera of 36 obese and 15 lean women. The expression of IDO1 in corresponding omental and subcutaneous adipose tissues and liver was evaluated. Proinflammatory markers and T-cell subsets were analyzed in adipose tissue via the expression of CD14, IL-18, CD68, TNFα, CD3ε, FOXP3 [a regulatory T-cell (Treg) marker] and RORC (a Th 17 marker). In obese subjects, the ratio of kynurenine to tryptophan, which reflects IDO1 activation, is higher than in lean subjects. Furthermore, IDO1 expression in both adipose tissues and liver is increased and is inversely correlated with arterial blood pressure. Inflammation is associated with a T-cell infiltration in obese adipose tissue, with predominance of Thl7 in the omental compartment and of Treg in the subcutaneous depot. The Th17/Treg balance is decreased in subcutaneous fat and correlates with IDO1 activation. In contrast, in the omental compartment, despite IDO1 activation, the Th17/Treg balance control is impaired. Taken together, our results suggest that IDO1 activation represents a local compensatory mechanism to limit obesity-induced inflammation and hypertension.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Hauts-de-France</li><li>Nord-Pas-de-Calais</li></region><settlement><li>Lille</li><li>Londres</li></settlement></list><tree><country name="France"><region name="Hauts-de-France"><name sortKey="Wolowczuk, Isabelle" sort="Wolowczuk, Isabelle" uniqKey="Wolowczuk I" first="Isabelle" last="Wolowczuk">Isabelle Wolowczuk</name></region><name sortKey="Allorge, Delphine" sort="Allorge, Delphine" uniqKey="Allorge D" first="Delphine" last="Allorge">Delphine Allorge</name><name sortKey="Caiazzo, Robert" sort="Caiazzo, Robert" uniqKey="Caiazzo R" first="Robert" last="Caiazzo">Robert Caiazzo</name><name sortKey="Consortium, Abos" sort="Consortium, Abos" uniqKey="Consortium A" first="Abos" last="Consortium">Abos Consortium</name><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><name sortKey="Hennart, Benjamin" sort="Hennart, Benjamin" uniqKey="Hennart B" first="Benjamin" last="Hennart">Benjamin Hennart</name><name sortKey="Leloire, Audrey" sort="Leloire, Audrey" uniqKey="Leloire A" first="Audrey" last="Leloire">Audrey Leloire</name><name sortKey="Pattou, Francois" sort="Pattou, Francois" uniqKey="Pattou F" first="François" last="Pattou">François Pattou</name><name sortKey="Pigeyre, Marie" sort="Pigeyre, Marie" uniqKey="Pigeyre M" first="Marie" last="Pigeyre">Marie Pigeyre</name><name sortKey="Poulain Godefroy, Odile" sort="Poulain Godefroy, Odile" uniqKey="Poulain Godefroy O" first="Odile" last="Poulain-Godefroy">Odile Poulain-Godefroy</name><name sortKey="Raverdy, Violeta" sort="Raverdy, Violeta" uniqKey="Raverdy V" first="Violeta" last="Raverdy">Violeta Raverdy</name><name sortKey="Soichot, Marion" sort="Soichot, Marion" uniqKey="Soichot M" first="Marion" last="Soichot">Marion Soichot</name><name sortKey="Taront, Solenne" sort="Taront, Solenne" uniqKey="Taront S" first="Solenne" last="Taront">Solenne Taront</name></country><country name="Australie"><noRegion><name sortKey="Bessede, Alban" sort="Bessede, Alban" uniqKey="Bessede A" first="Alban" last="Bessede">Alban Bessede</name></noRegion><name sortKey="Guillemin, Gilles J" sort="Guillemin, Gilles J" uniqKey="Guillemin G" first="Gilles J." last="Guillemin">Gilles J. Guillemin</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 005792 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 005792 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= Pascal:12-0416204
|texte= Tryptophan metabolism activation by indoleamine 2,3-dioxygenase in adipose tissue of obese women: an attempt to maintain immune homeostasis and vascular tone
}}
| This area was generated with Dilib version V0.6.33. |  |